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Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms

Frontiers of Medicine Pages 805-822 doi: 10.1007/s11684-023-1025-7

Abstract: Recently, numerous studies have revealed that metabolic reprogramming of tumor cells restrains immuneresponses by remodeling the tumor microenvironment (TME) with various products of metabolism, and combinationcrucial immune checkpoints (CTLA-4, PD-1, and PD-L1) to influence ICB therapy and propose potential combinedimmunotherapeutic strategies co-targeting tumor metabolic pathways and immune checkpoints.

Keywords： CTLA-4 PD-1 PD-L1 immune checkpoint blockade (ICB) metabolic reprogramming combined tumor therapeutic

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Immunotherapeutic effects on murine pancreatic carcinoma by β-elemene combined with dendritic cells modified

TAN Guang, WANG Zhongyu, CHE Luanqing, YIN Shuo

Frontiers of Medicine 2007, Volume 1, Issue 1, Pages 41-45 doi: 10.1007/s11684-007-0008-4

Abstract: Functional cytokines can enhance dendritic cell anti-tumor immune responses.

Keywords： Functional experiment anti-tumor dendritic clinical

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Heterogeneity of the tumor immune microenvironment and clinical interventions

Frontiers of Medicine 2023, Volume 17, Issue 4, Pages 617-648 doi: 10.1007/s11684-023-1015-9

Abstract: Heterogeneity of the tumor immune microenvironment and clinical interventions

Keywords： Heterogeneity tumor immune

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Proteins moonlighting in tumor metabolism and epigenetics

Lei Lv, Qunying Lei

Frontiers of Medicine 2021, Volume 15, Issue 3, Pages 383-403 doi: 10.1007/s11684-020-0818-1

Abstract: interplay of multiple signaling pathways and restrained by oxygen and nutrient accessibility in the tumorThe signal−moonlighting protein−metabolism axis facilitates the adaptation of tumor cells under varying

Keywords： moonlighting function tumor metabolism epigenetics

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Complex interplay between tumor microenvironment and cancer therapy

Minhong Shen, Yibin Kang

Frontiers of Medicine 2018, Volume 12, Issue 4, Pages 426-439 doi: 10.1007/s11684-018-0663-7

Abstract:

Tumor microenvironment (TME) is comprised of cellular and non-cellular components that exist withinand around the tumor mass.Given the importance of TME in tumor progression and therapy resistance, strategies that remodel TME

Keywords： tumor microenvironment therapy response treatment resistance

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Immunosuppressive tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma

Frontiers of Medicine 2023, Volume 17, Issue 4, Pages 699-713 doi: 10.1007/s11684-022-0972-8

Abstract: However, the underlying mechanism of alterations in the tumor microenvironments resulting in CAR-T cellSingle-cell RNA sequencing results were obtained from core needle biopsy tumor samples collected fromM2-subtype macrophages were significantly involved in both in vivo and in vitro anti-tumorImmunosuppressive tumor microenvironments persisted before CAR-T cell therapy, during both cell expansionThus, our findings provided a clinical rationale for targeting tumor microenvironments and reprogramming

Keywords： anti-CD19 chimeric antigen receptor T immunotherapy diffuse large B cell lymphoma tumor microenvironment tumor-associated macrophage metabolism

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Combined gemcitabine and CHK1 inhibitor treatment induces apoptosis resistance in cancer stem cell-likecells enriched with tumor spheroids from a non-small cell lung cancer cell line

Douglas D. Fang, Joan Cao, Jitesh P. Jani, Konstantinos Tsaparikos, Alessandra Blasina, Jill Kornmann, Maruja E. Lira, Jianying Wang, Zuzana Jirout, Justin Bingham, Zhou Zhu, Yin Gu, Gerrit Los, Zdenek Hostomsky, Todd VanArsdale

Frontiers of Medicine 2013, Volume 7, Issue 4, Pages 462-476 doi: 10.1007/s11684-013-0270-6

Abstract:

Evaluating the effects of novel drugs on appropriate tumor models has become crucial for developingIn this study, we demonstrate that a subset of cancer cells with CSC properties may be enriched into tumorunderlying the drug resistance of CSCs and for guiding the development of better therapies that can inhibit tumor

Keywords： drug resistance cancer stem cell checkpoint kinase 1 (CHK1) PF-00477736 lung cancer tumorigenicity

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Progress in tumor vascular normalization for anticancer therapy: challenges and perspectives

Bingxue Shang, Zhifei Cao, Quansheng Zhou

Frontiers of Medicine 2012, Volume 6, Issue 1, Pages 67-78 doi: 10.1007/s11684-012-0176-8

Abstract: Although the current antiangiogenic drugs reduce the density of tumor blood vessels and result in tumor, which fosters tumor cells to become more aggressive and metastatic.on the pioneering work on tumor blood vessels by several other researchers.roles in tumor neovascularization, growth, and metastasis.Therefore, multiple-targeting of vasculogenic tumor cells and genes may improve the efficacy of tumor

Keywords： angiogenesis vasculogenesis neovascularization tumor vasculature normalization traditional Chinese medicine

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Natural killer cell lines in tumor immunotherapy

Min Cheng, Jian Zhang, Wen Jiang, Yongyan Chen, Zhigang Tian

Frontiers of Medicine 2012, Volume 6, Issue 1, Pages 56-66 doi: 10.1007/s11684-012-0177-7

Abstract: genetically modifying NK cell lines by increasing their expression of cytokines and engineering chimeric tumorIn this review, NK cells in tumor immunotherapy are discussed, and a list of therapeutic NK cell lines

Keywords： natural killer cell natural killer cell line tumor immunotherapy genetic modification

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Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy

Kai Shi, Matthew Haynes, Leaf Huang

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4, Pages 676-684 doi: 10.1007/s11705-017-1640-4

Abstract: Specifically, reversing the immune-suppressive effects of the tumor microenvironment, mediated by a varietylab has implemented various nano-vaccines based on the lipid-coated calcium phosphate platform for combined

Keywords： vaccine nanoparticle tumor immunotherapy microenvironment

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carmustine loaded natural extracellular matrix hydrogel for inhibition of glioblastoma recurrence after tumor

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 4, Pages 536-545 doi: 10.1007/s11705-021-2067-5

Abstract: recurrence after tumor resection, both free BCNU and BCNU- poly (lactic-co-glycolic acid) (the ratioThe hydrogel was injected into the resection cavity of a glioblastoma tumor immediately after tumor removalFree drugs were released instantly to kill the residual tumor cells, while drugs in nanoparticles werecontinuously released to achieve a continuous and effective inhibition of the residual tumor cells forThese combined actions effectively restricted tumor growth in rats.

Keywords： BCNU glioblastoma recurrence tumor resection nanoparticles hydrogel

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Bacteria-mediated tumor-targeted delivery of tumstatin (54-132) significantly suppresses tumor growth

Frontiers of Medicine 2022, Volume 16, Issue 6, Pages 873-882 doi: 10.1007/s11684-022-0925-2

Abstract: Tumor growth is an angiogenesis-dependent process and accompanied by the formation of hypoxic areas.Tumstatin is a tumor-specific angiogenesis inhibitor that suppresses the proliferation and induces theTreatment with VNP-Tum5 effectively suppressed tumor growth and prolonged survival in the mouse modelThis study is the first to use tumstatin-transformed VNP20009 as a tumor-targeted system for treatmentof melanoma by combining anti-tumor and anti-angiogenic effects.

Keywords： Salmonella VNP20009 tumstatin B16F10 melanoma apoptosis angiogenesis

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Endostatin specifically targets both tumor blood vessels and lymphatic vessels

Wei Zhuo, Yang Chen, Xiaomin Song, Yongzhang Luo

Frontiers of Medicine 2011, Volume 5, Issue 4, Pages 336-340 doi: 10.1007/s11684-011-0163-5

Abstract: Recently, several studies demonstrated that endostatin also inhibits tumor lymphangiogenesis and lymphatic

Keywords： endostatin angiogenesis lymphangiogenesis nystatin internalization tumor

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Gene expression disparity in giant cell tumor of bone

Xiaohua PAN, Shuhua YANG, Deming XIAO, Yong DAI, Lili REN

Frontiers of Medicine 2009, Volume 3, Issue 1, Pages 49-56 doi: 10.1007/s11684-009-0012-y

Abstract: The aim of this paper was to study the differential gene expression of giant cell tumor of bone (GCTB

Keywords： giant cell tumor of bone gene microarray cDNA

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Identification of cancer stem cells provides novel tumor models for drug discovery

Douglas D. Fang, Danyi Wen, Yajun Xu

Frontiers of Medicine 2012, Volume 6, Issue 2, Pages 112-121 doi: 10.1007/s11684-012-0199-1

Abstract: Accumulating evidence suggests that CSCs are responsible for tumor initiation and progression, drug resistancetargeting CSC populations that is becoming increasingly important for eradicating CSCs in heterogeneous tumor

Keywords： cancer stem cell tumor model drug discovery

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Title Author Date Type Operation

Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms

Journal Article

Immunotherapeutic effects on murine pancreatic carcinoma by β-elemene combined with dendritic cells modified

TAN Guang, WANG Zhongyu, CHE Luanqing, YIN Shuo

Journal Article

Heterogeneity of the tumor immune microenvironment and clinical interventions

Journal Article

Proteins moonlighting in tumor metabolism and epigenetics

Lei Lv, Qunying Lei

Journal Article

Complex interplay between tumor microenvironment and cancer therapy

Minhong Shen, Yibin Kang

Journal Article

Immunosuppressive tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma

Journal Article

Combined gemcitabine and CHK1 inhibitor treatment induces apoptosis resistance in cancer stem cell-likecells enriched with tumor spheroids from a non-small cell lung cancer cell line

Journal Article

Progress in tumor vascular normalization for anticancer therapy: challenges and perspectives

Bingxue Shang, Zhifei Cao, Quansheng Zhou

Journal Article

Natural killer cell lines in tumor immunotherapy

Min Cheng, Jian Zhang, Wen Jiang, Yongyan Chen, Zhigang Tian

Journal Article

Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy

Kai Shi, Matthew Haynes, Leaf Huang

Journal Article

carmustine loaded natural extracellular matrix hydrogel for inhibition of glioblastoma recurrence after tumor

Journal Article